Brain Health - June 20th, 2022 Episode

Updated: Oct 17





Key Facts from WHO

  • Dementia is a syndrome in which there is deterioration in cognitive function beyond what might be expected from the usual consequences of biological aging.

  • Although dementia mainly affects older people, it is not an inevitable consequence of aging.

  • Currently, more than 55 million people live with dementia worldwide, and there are nearly 10 million new cases every year.

  • Dementia results from a variety of diseases and injuries that primarily or secondarily affect the brain. Alzheimer's disease is the most common form of dementia and may contribute to 60-70% of cases. Other causes include vascular disease, dementia with Lewy bodies, and fronto-temporal dementia.

  • Dementia is currently the seventh leading cause of death among all diseases and one of the major causes of disability and dependency among older people globally.

  • Dementia has physical, psychological, social, and economic impacts, not only for people living with dementia but also for their carers, families, and society at large.

About 3% of adults ages 70 to 74 had dementia in 2019, compared with 22% of adults ages 85 to 89 and 33% of adults ages 90 and older. Women are slightly more likely to have dementia than men. Among adults ages 70 and older, 11% of women and 8% of men had dementia in 2019.


Someone in the world develops dementia every 3 seconds. There are over 55 million people worldwide living with dementia in 2020. This number will almost double every 20 years, reaching 78 million in 2030 and 139 million in 2050. Much of the increase will be in developing countries. Already 60% of people with dementia live in low and middle-income countries, but by 2050 this will rise to 71%. The fastest growth in the elderly population is taking place in China, India, and their south Asian and western Pacific neighbors.


Each year, an estimated 10 in every 100,000 individuals develop dementia with early-onset (prior to age 65). This corresponds to 350,000 new cases of early-onset dementia per year, globally.

BAD NEWS:

There are no treatments from big pharma.

The drugs “approved” to use in dementia patients reduce the symptomatic impact slightly but do NOT TREAT THE DISEASE. The Financial Drop Administration “approved” a $63,000 annual drug that its own science advisory panel told the director NOT to approve, but he decided that someone might spend some money on it if approved, thus helping the manufacturer gain back some investment (at the cost of the insurer or Medicare/taxpayer and the torture of false hope for the patient and family)


GOOD NEWS:


There is great evidence for early intervention with lifestyle changes that can prevent the disease in many people with a predisposition


There is also clinical evidence that dementia can be treated and reversed through a very intensive regimen outlined by Dr Dale Bredesen in his book End of Alzheimer’s: Reversing Cognitive Decline

https://www.barnesandnoble.com/w/the-end-of-alzheimers-dale-bredesen/1124998286?ean=9780735216211&st=AFF&2sid=Random%20House%20Inc_8373827_NA&sourceId=AFFRandom%20House%20Inc


A biased, narrow-minded, and deceptive rebuttal:

https://memory.ucsf.edu/sites/memory.ucsf.edu/files/CanWeTrustTheEnd2020.pdf

She questions the use of case studies because they are not double blind placebo controlled trials - many academics question the DBPCT as a tool for pharma but not necessarily the best way to get clinical answers

They don’t include a methods section - that is because the method is complex and highly personalized and precise

Too broad a patient population with many possible causes - that is the definition of dementia - these ivory tower docs want one cause and one treatment in a pill

Articles appeared in open access or so called predatory journals - other journals won’t accept articles that challenge the pharma narrative

Numerous published studies support this approach:

The initial ReCoDe trial:

Reversal of cognitive decline in Alzheimer’s disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931830/pdf/aging-08-1250.pdf

Further explanation and more cases of success:

Metabolic profiling distinguishes three subtypes of Alzheimer's disease

https://pubmed.ncbi.nlm.nih.gov/26343025/

ReCODE: A Personalized, Targeted, Multi-Factorial Therapeutic Program for Reversal of Cognitive Decline

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533598/pdf/biomedicines-09-01348.pdf

In the case of AD, there is not a single therapeutic that exerts anything beyond a marginal, unsustained, symptomatic effect. This suggests that the monotherapeutic approach to drug development for AD may not be an optimal one, at least when used alone.

WHAT YOU CAN DO:

Physical Exercise

Grow hippocampus

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041121/pdf/pnas.201015950.pdf

https://www.sciencedirect.com/science/article/pii/S1053811917309138

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575139/pdf/nihms-439624.pdf

Food & Nutrition

Many western med sites like the Cleveland Clinic’s Healthy Brains website have some errors when they talk about diet. Due to the focus on sat fat in cardiology, they recommend limiting red meat, but studies show that increased red meat reduces the risk of dementia

https://pubmed.ncbi.nlm.nih.gov/30883348/

The real meat culprit is PROCESSED meat They looked at almost 500,000 in UK and for each 25 g additional daily dose of processed meats, there was a 50% increased risk

https://pubmed.ncbi.nlm.nih.gov/33748832/

Medical Health

The standard medical line is that red wine benefits the vascular system because of resveratrol. So what? alcohol causes brain shrinkage.

Make sure that diabetes heart disease and blood pressure are all controlled or eliminated

Sleep and Relaxation/stress reduction

Sleep apnea is a sleep disorder and it is a treatable cause of dementia

Poor quality sleep and sleep deprivation also contribute to cognitive decline

Mental Fitness

Use it or lose it

Social Interaction

We are not islands

Detoxification

Type 3 dementia is toxicity

Inhalational Alzheimer’s disease: an unrecognized—and treatable— epidemic

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789584/pdf/aging-08-304.pdf