Here we report that the BA.1, BA.2, BA.2.12.1, and BA.4/5 Omicron sublineages, which account for over 99% of all infections worldwide over the first half of 2022, have increased ACE2 binding affinity, decreased fusogenicity and markedly evade neutralizing antibody responses relative to the Wuhan-Hu-1 and Delta strains (3). Collectively, these data suggest that enhanced receptor engagement and immune evasion are key changes that may have promoted the rapid spread of these Omicron sublineages and could contribute to the current rise in prevalence of BA.4 and BA.5.
146 COVID-19 deaths were reported this week, a 3% increase from 142 reported last week. All 146 deaths were eligible for a third dose of COVID-19 vaccine and 100 (68%) had received a third dose. Five deaths were in people aged under 65 years.
Overall, these data underscore the magnitude of evasion of polyclonal plasma neutralizing antibody responses for Omicron sublineages in humans after primary vaccine series or infection (resulting from the accumulation of S mutations (12)), with a subtle but consistently more marked effect for BA.1 and even more so for BA.4/5 compared to BA.2 and BA.2.12.1.
Protection against severe reinfection remains very strong, with no evidence for waning, irrespective of variant, for over 14 months after primary infection.
Effectiveness of a previous pre-Omicron infection against symptomatic BA.4/BA.5 reinfection was 15.1% (95% CI: -47.1-50.9%), and against any BA.4/BA.5 reinfection irrespective of symptoms was 28.3% (95% CI: 11.4-41.9%)
Effectiveness of a previous Omicron infection against symptomatic BA.4/BA.5 reinfection was 76.1% (95% CI: 54.9-87.3%), and against any BA.4/BA.5 reinfection was 79.7% (95% CI: 74.3-83.9%).
Novavax's product is a protein subunit vaccine that contains the SARS-CoV-2 spike protein plus an adjuvant to enhance the recipient's immune response.
Approved EUA as a primary vaccine not booster
Good evidence for boosting antibody production with less Transient Systemic Reactogenicity
Not approved because efficacy trial for boosting still ongoing and changes made to manufacturing process
FDA Approved therapies
Remdesivir (Veklury) - HIV anti-retroviral
People who take it in one study had a 50% better chance of recovery at 15 days and may recover 5 days sooner
Baricitinib (Olumiant) -
Serious infections, cancer, major cardiac events, blood clots, allergy, stomach or intestinal tears
Emergency use auth:
Wow. Just wow…
History of clinically significant hypersensitivity reactions to the active ingredients (nirmatrelvir or ritonavir) or any other components. (4)
Co-administration with drugs highly dependent on CYP3A for clearance and for which elevated concentrations are associated with serious and/or life-threatening reactions. (4, 7.3)
Co-administration with potent CYP3A inducers where significantly reduced nirmatrelvir or ritonavir plasma concentrations may be associated with the potential for loss of virologic response and possible resistance. (4)
Paxlovid, a drug with 120 important drug interactions across 25 different classes of very commonly prescribed medications. It cannot be given concurrently with 75 of them and you have to adjust doses with an additional 29. Even Biden had to be taken off of two of his medications to be treated with it.
Treatment with fluvoxamine (100 mg twice daily for 10 days) among high-risk outpatients with early diagnosed COVID-19 reduced the need for hospitalisation defined as retention in a COVID-19 emergency setting or transfer to a tertiary hospital.
These findings suggest that fluvoxamine, a widely available and inexpensive treatment for outpatients with COVID-19, was associated with a reduction in hospitalizations.